2010, 2009, 2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999, 1998

←back 2010next→

• Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga JI, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H.
  
  Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.
  J Biol Chem 285:11681-91, 2010. [Abstract] [PDF]
  
  

←back 2009 next→

• Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, Takahashi M, Tazoe F, Wada T, Ohta K, Takanashi M, Kumagai M, Nishi M, Takase S, Yahagi N, Yagyu H, Ohashi K, Nagai R, Kadowaki T, Furukawa Y, Ishibashi S.
  
  Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
  Cell Metab 10:219-28, 2009. [Abstract] [PDF]
  
  
• Sekiya M, Yahagi N, Tamura Y, Okazaki H, Igarashi M, Ohta K, Takanashi M, Kumagai M, Takase S, Nishi M, Takeuchi Y, Izumida Y, Kubota M, Ohashi K, Iizuka Y, Yagyu H, Gotoda T, Nagai R, Shimano H, Yamada N, Kadowaki T, Ishibashi S, Osuga JI.
  
  Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep(ob)(/)(ob) mice.
  Biochem Biophys Res Commun 387:511-5, 2009. [Abstract] [PDF]
  
  

←back 2008 next→

• Ishikawa M, Iwasaki Y, Yatoh S, Kato T, Kumadaki S, Inoue N, Yamamoto T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Yamada N, Shimano H.
  
  Overexpression of nuclear SREBP-2 in pancreatic beta -cells results in cholesterol accumulation leading to insulin secretion defects and diabetes:A new model for beta -cell lipotoxicity.
  J Lipid Res 49:2524-34, 2008. [Abstract] [PDF]
  
  
• Sekiya M, Osuga J, Yahagi N, Okazaki H, Tamura Y, Igarashi M, Takase S, Harada K, Okazaki S, Iizuka Y, Ohashi K, Yagyu H, Okazaki M, Gotoda T, Nagai R, Kadowaki T, Shimano H, Yamada N, Ishibashi S.
  
  Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.
  J Lipid Res 49:1829-38, 2008. [Abstract] [PDF]
  
  
• Okazaki H, Igarashi M, Nishi M, Sekiya M, Tajima M, Takase S, Takanashi M, Ohta K, Tamura Y, Okazaki S, Yahagi N, Ohashi K, Amemiya-Kudo M, Nakagawa Y, Nagai R, Kadowaki T, Osuga J, Ishibashi S.
  
  Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
  J Biol Chem 283:33357-64, 2008. [Abstract] [PDF]
  
  
• Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N.
  
  Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.
  Diabetes 57:2382-92, 2008. [Abstract] [PDF]
  
  
• Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H.
  
  Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity and insulin resistance.
  J Biol Chem 283:21220-9, 2008. [Abstract] [PDF] [Supplemental Data]
  
  
• Kumadaki S, Matsuzaka T, Kato T, Yahagi N, Yamamoto T, Okada S, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H.
  
  Mouse Elovl-6 promoter is an SREBP target.
  Biochem Biophys Res Commun 368:261-6, 2008. [Abstract] [PDF]
  
  

←back 2007 next→

• Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga JI, Yamada N.
  
  Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
  Nature Medicine 13:1193-1202, 2007. [Abstract] [PDF] [Supplemental Data]
  
  
• Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y, Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI, Shimano H.
  
  In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.
  Biochem Biophys Res Commun 363:329-35, 2007. [Abstract] [PDF]
  
  
• Nakakuki M, Shimano H, Inoue N, Tamura M, Matsuzaka T, Nakagawa Y, Yahagi N, Toyoshima H, Sato R, Yamada N.
  
  A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.
  FEBS J 274:4440-52, 2007. [Abstract] [PDF]
  
  
• Sekiya M, Yahagi N, Matsuzaka T, Takeuchi Y, Nakagawa Y, Takahashi H, Okazaki H, Iizuka Y, Ohashi K, Gotoda T, Ishibashi S, Nagai R, Yamazaki T, Kadowaki T, Yamada N, Osuga JI, Shimano H.
  
  Sterol regulatory element-binding protein (SREBP) -1-independent regulation of lipogenic gene expression in adipocytes.
  J Lipid Res 48:1581-91, 2007. [Abstract] [PDF]
  
  
• Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N.
  
  Protein kinase A suppresses sterol regulatory element-binding protein-1c expression via phosphorylation of liver X receptor in the liver.
  J Biol Chem 282:11687-95, 2007. [Abstract] [PDF]
  
  

←back 2006 next→

• Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N.
  
  Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
  Cell Metabolism 4:143-54, 2006. [Abstract] [PDF] [Supplemental Data]
  
  
• Okazaki H, Igarashi M, Nishi M, Tajima M, Sekiya M, Okazaki S, Yahagi N, Ohashi K, Tsukamoto K, Amemiya-Kudo M, Matsuzaka T, Shimano H, Yamada N, Aoki J, Morikawa R, Takanezawa Y, Arai H, Nagai R, Kadowaki T, Osuga J, Ishibashi S.
  
  Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
  Diabetes 55:2091-7, 2006. [Abstract] [PDF]
  
  
• Okazaki H, Tazoe F, Okazaki S, Isoo N, Tsukamoto K, Sekiya M, Yahagi N, Iizuka Y, Ohashi K, Kitamine T, Tozawa R, Inaba T, Yagyu H, Okazaki M, Shimano H, Shibata N, Arai H, Nagai R, Kadowaki T, Osuga J, Ishibashi S.
  
  Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
  J Lipid Res 47:1950-8, 2006. [Abstract] [PDF]
  
  
• Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.
  
  TFE3, a novel transcription factor for hepatic IRS-2 and insulin signals, ameliorates diabetes.
  Nature Medicine 12:107-13, 2006. [Abstract] [PDF]
  
  

←back 2005 next→

• Inoue N, Shimano H, Nakakuki M, Matsuzaka T, Nakagawa Y, Yamamoto T, Sato R, Takahashi A, Sone H, Yahagi N, Suzuki H, Toyoshima H, Yamada N.
  
  Lipid synthetic transcription factor SREBP-1a activates p21 WAF1/CIP1, a universal cyclin-dependent kinase inhibitor.
  Mol Cell Biol 25:8938-47, 2005. [Abstract] [PDF]
  
  
• Amemiya-Kudo M, Oka J, Ide T, Matsuzaka T, Sone H, Yoshikawa T, Yahagi N, Ishibashi S, Osuga JI, Yamada N, Murase T, Shimano H.
  
  SREBPs activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.
  J Biol Chem 280:34577-89, 2005. [Abstract] [PDF]
  
  
• Najima Y, Yahagi N, Takeuchi Y, Matsuzaka T, Sekiya M, Nakagawa Y, Amemiya-Kudo M, Okazaki H, Okazaki S, Tamura Y, Iizuka Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Yamada N, Osuga JI, Shimano H.
  
  High mobility group protein-B1 (HMGB1) interacts with sterol regulatory element-binding proteins (SREBPs) to enhance their DNA binding.
  J Biol Chem 280:27523-32, 2005. [Abstract] [PDF]
  
  
• Yahagi N, Shimano H, Hasegawa K, Ohashi K, Matsuzaka T, Najima Y, Sekiya M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Nagai R, Ishibashi S, Kadowaki T, Makuuchi M, Ohnishi S, Osuga JI, Yamada N.
  
  Coordinate activation of lipogenic enzymes in hepatocellular carcinoma.
  Eur J Cancer 41:1316-22, 2005. [Abstract] [PDF]
  
  
• Yahagi N and Shimano H.
  
  Microarray analyses of SREBP-1 target genes.
  p. 237-248. In Berger A and Roberts MA (ed.), Unraveling Lipid Metabolism with Microarrays, CRC Press, New York, 2005. [Abstract] [PDF]
  
  
• Takahashi A, Motomura K, Kato T, Yoshikawa T, Nakagawa Y, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N, Shimano H.
  
  Transgenic mice overexpressing nuclear SREBP-1c in pancreatic {beta}-cells.
  Diabetes 54:492-9, 2005. [Abstract] [PDF]
  
  

←back 2004 next→

• Tamura Y, Osuga JI, Adachi H, Tozawa RI, Takanezawa Y, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Koizumi H, Inaba T, Yagyu H, Kamada N, Suzuki H, Shimano H, Kadowaki T, Tsujimoto M, Arai H, Yamada N, Ishibashi S.
  
  Scavenger receptor expressed by endothelial cells-I mediates the uptake of acetylated LDL by macrophages stimulated with lipopolysaccharide.
  J Biol Chem 279:30938-44, 2004. [Abstract] [PDF]
  
  
• Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, Yamada N.
  
  SREBPs suppress IRS-2-mediated insulin signalling in the liver.
  Nature Cell Biology 6:351-7, 2004. [Abstract] [PDF] [Supplemental Data]
  
  
• Yahagi N, Shimano H, Matsuzaka T, Sekiya M, Najima Y, Okazaki S, Okazaki H, Tamura Y, Iizuka Y, Inoue N, Nakagawa Y, Takeuchi Y, Ohashi K, Harada K, Gotoda T, Nagai R, Kadowaki T, Ishibashi S, Osuga JI, Yamada N.
  
  p53 involvement in the pathogenesis of fatty liver disease.
  J Biol Chem 279:20571-5, 2004. [Abstract] [PDF]
  
  
• Sekiya M, Osuga JI, Okazaki H, Yahagi N, Harada K, Shen WJ, Tamura Y, Tomita S, Iizuka Y, Ohashi K, Okazaki M, Sata M, Nagai R, Fujita T, Shimano H, Kraemer FB, Yamada N, Ishibashi S.
  
  Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lepob/ob mice.
  J Biol Chem 279:15084-90, 2004. [Abstract] [PDF]
  
  
• Matsuzaka T, Shimano H, Yahagi N, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Tomita S, Sekiya M, Hasty A, Nakagawa Y, Sone H, Toyoshima H, Ishibashi S, Osuga J, Yamada N.
  
  Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
  Diabetes 53:560-9, 2004. [Abstract] [PDF]
  
  
• Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N.
  
  SREBP-1 interacts with HNF-4alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
  J Biol Chem 279:12027-35, 2004. [Abstract] [PDF]
  
  

←back 2003 next→

• Kajihara M, Sone H, Amemiya M, Katoh Y, Isogai M, Shimano H, Yamada N, Takahashi S.
  
  Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
  Biochem Biophys Res Commun 312:831-42, 2003. [Abstract] [PDF]
  
  
• Sekiya M, Yahagi N, Matsuzaka T, Najima Y, Nakakuki M, Nagai R, Ishibashi S, Osuga J, Yamada N, Shimano H.
  
  Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
  Hepatology 38:1529-39, 2003. [Abstract] [PDF]
  
  
• Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T.
  
  Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
  Diabetes 52:2905-13, 2003. [Abstract] [PDF]
  
  
• Harada K, Shen WJ, Patel S, Natu V, Wang J, Osuga JI, Ishibashi S, Kraemer FB.
  
  Resistance to high fat diet-induced obesity associated with altered expression of adipose specific genes in hormone-sensitive lipase deficient mice.
  Am J Physiol Endocrinol Metab 285:E1182-95, 2003. [Abstract] [PDF]
  
  
• Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Sekiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Yamada N, Ishibashi S.
  
  Early embryonic lethality caused by targeted disruption of the HMG-CoA reductase gene.
  J Biol Chem 278:42936-41, 2003. [Abstract] [PDF]
  
  
• Tajima M, Hirabayashi S, Yao I, Shirasawa M, Osuga J, Ishibashi S, Fujita T, Hata Y.
  
  Roles of immunoglobulin-like loops of junctional cell adhesion molecule 4; involvement in the subcellular localization and the cell adhesion.
  Genes Cells 8:759-68, 2003. [Abstract] [PDF]
  
  
• Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y.
  
  JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.
  Mol Cell Biol 23:4267-82, 2003. [Abstract] [PDF]
  
  
• Yahagi N, Shimano H, Matsuzaka T, Najima Y, Sekiya M, Nakagawa Y, Ide T, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Gotoda T, Nagai R, Kimura S, Ishibashi S, Osuga JI, Yamada N.
  
  p53 activation in adipocytes of obese mice.
  J Biol Chem 278:25395-400, 2003. [Abstract] [PDF]
  
  
• Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga JI, Ishibashi S, Yamada N.
  
  Cross-talk between peroxisome proliferator activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. PPARs suppress sterol regulatory element-binding protein-1c promoter through inhibition of LXR signaling.
  Mol Endocrinol 17:1240-54, 2003. [Abstract] [PDF]
  
  
• Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga JI, Ishibashi S, Yamada N.
  
  Cross-talk between peroxisome proliferator activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
  Mol Endocrinol 17:1255-67, 2003. [Abstract] [PDF]
  
  
• Tamura Y, Adachi H, Osuga JI, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S.
  
  FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
  J Biol Chem 278:12613-7, 2003. [Abstract] [PDF]
  
  

←back 2002 next→

• Okazaki H, Osuga J, Tamura Y, Yahagi N, Tomita S, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Kimura S, Gotoda T, Shimano H, Yamada N, Ishibashi S.
  
  Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
  Diabetes 51:3368-75, 2002. [Abstract] [PDF]
  
  
• Tamura Y, Ishibashi S, Gotoda T, Yasufuku-Takano J, Takano K, Ueki K, Yamashita S, Iizuka Y, Yahagi N, Shionoiri F, Okazaki H, Ohashi K, Osuga J, Harada K, Shimano H, Fujita T, Yamada N, Kimura S.
  
  A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.
  Endocr J 49:425-31, 2002. [Abstract]
  
  
• Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga JI, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.
  
  Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
  J Lipid Res 43:1220-35, 2002. [Abstract] [PDF]
  
  
• Okazaki H, Osuga JI, Tsukamoto K, Isoo N, Kitamine T, Tamura Y, Tomita S, Sekiya M, Yahagi N, Iizuka Y, Ohashi K, Harada K, Gotoda T, Shimano H, Kimura S, Nagai R, Yamada N, Ishibashi S.
  
  Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
  J Biol Chem 277:31893-9, 2002. [Abstract] [PDF]
  
  
• Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, Hasty AH, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Takahashi A, Yato S, Sone H, Ishibashi S, Yamada N.
  
  Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
  J Lipid Res 43:911-20, 2002. [Abstract] [PDF]
  
  
• Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.
  
  Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
  J Biol Chem 277:19353-7, 2002. [Abstract] [PDF]
  
  
• Matsuzaka T, Shimano H, Yahagi N, Amemiya-Kudo M, Yoshikawa T, Hasty AH, Tamura Y, Osuga J, Okazaki H, Iizuka Y, Takahashi A, Sone H, Gotoda T, Ishibashi S, Yamada N.
  
  Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.
  J Lipid Res 43:107-14, 2002. [Abstract] [PDF]
  
  
• Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga J, Gotoda T, Ishibashi S, Yamada N.
  
  Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
  J Biol Chem 277:1705-11, 2002. [Abstract] [PDF]
  
  
• Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H.
  
  Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
  Arterioscler Thromb Vasc Biol 22:1310-5, 2002. [Abstract] [PDF]
  
  
• Kraemer FB, Shen WJ, Natu V, Patel S, Osuga J, Ishibashi S, Azhar S.
  
  Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences.
  Endocrinology 143:801-6, 2002. [Abstract] [PDF]
  
  
• Sone H, Shimano H, Sakakura Y, Inoue N, Amemiya-Kudo M, Yahagi N, Osawa M, Suzuki H, Yokoo T, Takahashi A, Iida K, Toyoshima H, Iwama A, Yamada N.
  
  Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.
  Am J Physiol Endocrinol Metab 282:E222-30, 2002. [Abstract] [PDF]
  
  

←back 2001 next→

• Chiwata T, Aragane K, Fujinami K, Kojima K, Ishibashi S, Yamada N, Kusunoki J.
  
  Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.
  Br J Pharmacol 133:1005-12, 2001. [Abstract] [PDF]
  
  
• Tozawa R, Ishibashi S, Osuga J, Yamamoto K, Yagyu H, Ohashi K, Tamura Y, Yahagi N, Iizuka Y, Okazaki H, Harada K, Gotoda T, Shimano H, Kimura S, Nagai R, Yamada N.
  
  Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.
  J Biol Chem 276:12624-8, 2001. [Abstract] [PDF]
  
  
• Perrey S, Ishibashi S, Kitamine T, Osuga J, Yagyu H, Chen Z, Shionoiri F, Iizuka Y, Yahagi N, Tamura Y, Ohashi K, Harada K, Gotoda T, Yamada N.
  
  The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.
  Atherosclerosis 154:51-60, 2001. [Abstract] [PDF]
  
  
• Perrey S, Ishibashi S, Yahagi N, Osuga J, Tozawa R, Yagyu H, Ohashi K, Gotoda T, Harada K, Chen Z, Iizuka Y, Shionoiri F, Yamada N.
  
  Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
  Metabolism 50:36-40, 2001. [Abstract]
  
  
• Chen Z, Ishibashi S, Perrey S, Osuga J, Gotoda T, Kitamine T, Tamura Y, Okazaki H, Yahagi N, Iizuka Y, Shionoiri F, Ohashi K, Harada K, Shimano H, Nagai R, Yamada N.
  
  Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
  Arterioscler Thromb Vasc Biol 21:372-7, 2001. [Abstract] [PDF]
  
  
• Ishibashi S.
  
  Lipoprotein(a) and atherosclerosis.
  Arterioscler Thromb Vasc Biol 21:1-2, 2001. [PDF]
  
  
• Shimano H.
  
  Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes.
  Prog Lipid Res 40:439-52, 2001. [Abstract] [PDF]
  
  
• Iizuka Y, Gotoda T, Ishibashi S, Yamada N.
  
  CD36 deficiency and insulin resistance.
  Lancet 358:242; discussion 244, 2001. [PDF]
  
  
• Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, Perrey S, Iizuka Y, Tamura Y, Amemiya-Kudo M, Yoshikawa T, Okazaki H, Ohashi K, Harada K, Matsuzaka T, Sone H, Gotoda T, Nagai R, Ishibashi S, Yamada N.
  
  Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
  J Biol Chem 276:37402-8, 2001. [Abstract] [PDF]
  
  
• Yoshikawa T, Shimano H, Chen Z, Ishibashi S, Yamada N.
  
  Effects of Probucol on Atherosclerosis of apoE-Deficient or LDL Receptor-Deficient Mice.
  Horm Metab Res 33:472-9, 2001. [Abstract]
  
  
• Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty A H, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N.
  
  Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
  Mol Cell Biol 21:2991-3000, 2001. [Abstract] [PDF]
  
  

←back 2000 next→

• Yagyu H, Kitamine T, Osuga J, Tozawa R, Chen Z, Kaji Y, Oka T, Perrey S, Tamura Y, Ohashi K, Okazaki H, Yahagi N, Shionoiri F, Iizuka Y, Harada K, Shimano H, Yamashita H, Gotoda T, Yamada N, Ishibashi S.
  
  Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
  J Biol Chem 275:21324-30, 2000. [Abstract] [PDF]
  
  
• Ohashi K, Ishibashi S, Osuga J, Tozawa R, Harada K, Yahagi N, Shionoiri F, Iizuka Y, Tamura Y, Nagai R, Illingworth D R, Gotoda T, Yamada N.
  
  Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
  J Lipid Res 41:1199-1204, 2000. [Abstract] [PDF]
  
  
• Yoshida T, Gotoda T, Okubo M, Iizuka Y, Ishibashi S, Kojima T, Murakami T, Murase T, Yamada N.
  
  A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly188Glu mutation prevalent worldwide.
  J Atheroscler Thromb 7:45-49, 2000. [Abstract]
  
  
• Shimano H.
  
  Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver.
  Trends Cardiovasc Med 10:275-8, 2000. [Abstract] [PDF]
  
  
• Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, Shionoiri F, Yahagi N, Kraemer F B, Tsutsumi O, Yamada N.
  
  Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.
  Proc Natl Acad Sci U S A 97:787-92, 2000. [Abstract] [PDF]
  
  
• Hasty AH, Shimano H, Yahagi N, Amemiya-Kudo M, Perrey S, Yoshikawa T, Osuga J, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.
  
  Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
  J Biol Chem 275:31069-77, 2000. [Abstract] [PDF]
  
  
• Abe H, Yamada N, Ishibashi S, Makuuchi M.
  
  Chronic inhibitory effect of insulin on plasma lipid concentrations in rats with transplanted pancreas.
  Transplantation 69:2038-42, 2000. [Abstract]
  
  
• Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty A H, Okazaki H, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.
  
  Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
  J Biol Chem 275:31078-85, 2000. [Abstract] [PDF]
  
  
• Sato R, Okamoto A, Inoue J, Miyamoto W, Sakai Y, Emoto N, Shimano H, Maeda M.
  
  Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins.
  J Biol Chem 275:12497-502, 2000. [Abstract] [PDF]
  
  
• Gotoda T, Iizuka Y, Yamada N.
  
  Complex connection between CD36 and atherosclerosis, lipid metabolism, and insulin resistance syndromes.
  Curr Atheroscler Rep 2:453-4, 2000.
  
  
• Nagahora H, Okada T, Yahagi N, Chong JA, Mandel G, Okamura Y.
  
  Diversity of voltage-gated sodium channels in the ascidian larval nervous system.
  Biochem Biophys Res Commun 275:558-64, 2000. [Abstract]
  
  

←back 1999 next→

• Okubo M, Inoue S, Horinishi A, Ogihara T, Kaneko K, Gotoda T, Yamada N, Murase T.
  
  Detection of a new compound heterozygote(del G916/G1401A) for lipoprotein lipase deficiency and a comparative haplotype analysis of the mutant lipoprotein lipase gene from Japanese patients.
  Atherosclerosis 144:443-7, 1999. [PDF]
  
  
• Shimano H, Yahagi N, Amemiya-Kudo M, Hasty A H, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.
  
  Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
  J Biol Chem 274:35832-9, 1999. [Abstract] [PDF]
  
  
• Yahagi N, Shimano H, Hasty A H, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.
  
  A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
  J Biol Chem 274:35840-4, 1999. [Abstract] [PDF]
  
  
• Yokoyama I,Momomura S, Ohtake T, Yonekura K, Yang W, Kobayakawa N, Aoyagi T, Sugiura S, Yamada N, Ohtomo K, Sasaki Y, Omata M, Yazaki Y.
  
  Improvement of impaired myocardial vasodilatation due to diffuse coronary atherosclerosis in hypercholesterolemics after lipid-lowering therapy.
  Circulation 100:117-22, 1999. [Abstract] [PDF]
  
  
• Yokoyama I, Ohtake T, Momomura S, Yonekura K, Kobayakawa N, Aoyagi T, Sugiura S, Yamada N, Ohtomo K, Sasaki Y, Omata M, Yazaki Y.
  
  Insulin action on heart and skeletal muscle FDG uptake in patients with hypertriglyceridemia.
  J Nucl Med 40:1116-21, 1999. [Abstract]
  
  
• Yagyu H, Ishibashi S, Chen Z, Osuga J, Okazaki M, Perrey S, Kitamine T, Shimada M, Ohashi K, Harada K, Shionoiri F, Yahagi N, Gotoda T, Yazaki Y, Yamada N.
  
  Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
  J Lipid Res 40:1677-85, 1999. [Abstract] [PDF]
  
  
• Tozawa R, Ishibashi S, Osuga J, Yagyu H, Oka T, Chen Z, Ohashi K, Perrey S, Shionoiri F, Yahagi N, Harada K, Gotoda T, Yazaki Y, Yamada N.
  
  Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.
  J Biol Chem 274:30843-8, 1999. [Abstract] [PDF]
  
  
• Gotoda T, Iizuka Y, Kato N, Osuga J, Bihoreau M T, Murakami T, Yamori Y, Shimano H, Ishibashi S, Yamada N.
  
  Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance.
  Nat Genet 22:226-8, 1999. [PDF]
  
  
• Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL.
  
  Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.
  J Clin Invest 103:1067-76, 1999. [Abstract] [PDF]
  
  
• Gotoda T, Iizuka Y, Yamada N.
  
  Genetic analysis of spontaneously hypertensive rats(SHR), an animal model of hypertension and insulin resistance.
  Common Disease-Genetic and Pathogenetic Aspects of Multifactorial Diseases; Uehara Memorial Foundation Symposium-1999; Edited by Hiroo Imura, Masato Kasuga, Kazuwa Nakao; Excerpta Medica: 219-26, 1999.
  
  
• Yuan X, Ishibashi S, Hatakeyama S, Saito M, Nakayama J, Nikaido R, Haruyama T, Watanabe Y, Iwata H, Iida M, Sugimura H, Yamada N, Ishikawa F.
  
  Presence of telomeric G- strand tails in the telomerase catalytic subunit TERT knockout mice.
  Genes to Cells 4:563-72, 1999.
  
  
• Akabayashi A, Kai I, Takemura H, Okazaki H.
  
  Truth telling in the case of a pessimistic diagnosis in Japan.
  Lancet 354:1263, 1999.
  
  

1998 next→

• Horton JD, Bashmakov Y, Shimomura I, Shimano H.
  
  Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.
  Proc Natl Acad Sci U S A 95:5987-92, 1998. [Abstract] [PDF]
  
  
• Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H.
  
  Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
  J Clin Invest 101:2331-9, 1998. [Abstract] [PDF]
  
  
• Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD.
  
  Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver.
  J Biol Chem 273:35299-306, 1998. [Abstract] [PDF]
  
  
• Ohashi K, Ishibashi S, Yazaki Y, Yamada N.
  
  Improved glycemic control in a diabetic patient after discontinuation of allopurinol administration.
  Diabetes Care 21:192-3, 1998.
  
  
• Ohashi K, Ishibashi S, Yamamoto M, Osuga J, Yazaki Y, Yukawa S, Yamada N.
  
  A truncated species of apolipoprotein B (B-38.7) in a patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus.
  Arterioscler Thromb Vasc Biol 18:1330-4, 1998. [Abstract] [PDF]
  
  
• Okubo M, Aoyama Y, Harada K, Fukawa M, Tsukada T, Mokuno H, Yamada N, Murase T.
  
  A novel apolipoprotein E2 variant, E2Toranomon (Q187E), identified in a type III hyperlipoproteinemia patient with coronary atherosclerosis.
  Atherosclerosis 140:187-90, 1998.
  
  
• Murakami K, Ishibashi S, Yoshida Y, Yamada N, Akanuma Y.
  
  Lipoprotein(a) as a coronary risk factor in Japanese patients with Type II (non-insulin-dependent) diabetes mellitus. Relation with apolipoprotein(a) phenotypes.
  Diabetologia 41:1397-8, 1998. [PDF]
  
  
• Sun L, Ishibashi S, Osuga J, Harada K, Ohashi K, Gotoda T, Fukuo Y, Yazaki Y, Yamada N.
  
  Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.
  Arterioscler Thromb Vasc Biol 18:941-6, 1998. [Abstract] [PDF]
  
  
• Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E.
  
  Mice lacking melanin-concentrating hormone are hypophagic and lean.
  Nature 396:670-4, 1998. [Abstract] [PDF]
  
  
• Osuga J, Yonemoto M, Yamada N, Shimano H, Yagyu H, Ohashi K, Harada K, Kamei T, Yazaki Y, Ishibashi S.
  
  Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
  J Clin Invest 102:386-94, 1998. [Abstract] [PDF]
  
  
• Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, Shionoiri F, Yahagi N, Kadowaki T, Tamemoto H, Ishibashi S, Yazaki Y, Makuuchi M.
  
  Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
  J Clin Invest 101:1784-8, 1998. [Abstract] [PDF]
  
  
• Yokoyama I, Ohtake T, Momomura S, Yonekura K, Yamada N, Nishikawa J, Sasaki Y, Omata M.
  
  Organ-specific insulin resistance in patients with noninsulin-dependent diabetes mellitus and hypertension.
  J Nucl Med 39:884-9, 1998. [Abstract]
  
  

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